In this paper, we present a methodology to explore and evaluate the crosstalk noise and the profile of its variations, and the delay of interconnects through investigation of two groups of interconnect structures in nano scale VLSI circuits. The interconnect structures in the first group are considered to be partially coupled identical lines. In this case, by choosing proper values for different parameters, the crosstalk noise, when the victim line stays ahead of the aggressor line can be reduced up to 92% in comparison to when it is behind the aggressor line. The second group consists of a victim line shorter than the aggressor line. In this case, if the parameters are properly optimized, when the victim line is placed at the end of the aggressor line, the crosstalk noise can be reduced up to 86% in comparison to the case when the victim line is placed at the beginning.